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| Zhao,L.M.; Pang,A.X.. |
| Iodine-131 (131I) is widely used for the treatment of thyroid-related diseases. This study aimed to investigate the expression of p53 and BTG2 genes following 131I therapy in thyroid cancer cell line SW579 and the possible underlying mechanism. SW579 human thyroid squamous carcinoma cells were cultured and treated with 131I. They were then assessed for 131I uptake, cell viability, apoptosis, cell cycle arrest, p53 expression, and BTG2 gene expression. SW579 cells were transfected with BTG2 siRNA, p53 siRNA and siNC and were then examined for the same aforementioned parameters. When treated with a JNK inhibitor of SP600125 and 131I or with a NF-κB inhibitor of BMS-345541 and 131I, non-transfected SW579 cells were assessed in JNK/NFκB pathways. It was... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Iodine-131; P53; BTG2; SW579; Thyroid cancer; JNK/NF-κB pathways. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017000100608 |
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| Yang,Tianzheng; Zhai,Hongyan; Yan,Ruihong; Zhou,Zhenhu; Gao,Lei; Wang,Luqing. |
| Thyroid cancer is a common malignant tumor. Long non-coding RNA colon cancer-associated transcript 1 (lncRNA CCAT1) is highly expressed in many cancers; however, the molecular mechanism of CCAT1 in thyroid cancer remains unclear. Hence, this study aimed to investigate the effect of CCAT1 on human thyroid cancer cell line FTC-133. FTC-133 cells were transfected with CCAT1 expressing vector, CCAT1 shRNA, miR-143 mimic, and miR-143 inhibitor, respectively. After different treatments, cell viability, proliferation, migration, invasion, and apoptosis were measured. Moreover, the regulatory relationship of CCAT1 and miR-143, as well as miR-143 and VEGF were tested using dual-luciferase reporter assay. The relative expressions of CCAT1, miR-143, and VEGF were... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Thyroid cancer; CCAT1; MiR-143; VEGF; PI3K/AKT pathway; MAPK pathway. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018000600615 |
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| Zidane, Monia; Ren, Yen; Xhaard, Constance; Leufroy, Axelle; Côte, Suzanne; Dewailly, Eric; Noël, Laurent; Guérin, Thierry; Bouisset, Patrick; Bernagout, Solène; Paaoafaite, John; Iltis, Jacques; Taquet, Marc; Suhas, Eric; Rachédi, Frédérique; Boissin, Jean Louis; Sebbag, Joseph; Shan, Larrys; Bost-bezeaud, Frédérique; Petitdidier, Patrice; Rubino, Carole; Gardon, Jacques; De Vathaire, Florent. |
| Background: In French Polynesia, thyroid cancer mortality and incidence is reported to be the highest in the world. Excessive levels of non-essential trace elements (nETE) in the body are associated with several types of cancer. Objective: The present study aims to provide quantitative information on food contamination by mercury (Hg), lead (Pb), arsenic (As) and cadmium (Cd) in French Polynesia and its potential correlation with measurements performed in fingernails of Polynesians, and then to investigate the potential association between these nETE and different thyroid cancer risks. Methods: The study population included 229 interviewed cases and 373 interviewed controls We performed a descriptive analysis of Polynesian food and examined the association... |
| Tipo: Text |
Palavras-chave: Thyroid cancer; NETE; Diet; Fingernail; Case-control study. |
| Ano: 2019 |
URL: https://archimer.ifremer.fr/doc/00660/77190/78617.pdf |
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